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Objectives: We sought to evaluate whether there is a sex difference in the analgesic response to mu versus kappa opioids in the management of acute moderate to severe pain of injury in the emergency department.

Sex differences in kappa opioid receptor function and their potential impact on addiction

Methods: The study was a randomized, Adult wants casual sex IA Lovilia 50150, clinical trial comparing the prototypical mu-receptor agonist, morphine sulfate, to the prototypical kappa agonist, butorphanol. The primary endpoints were degree of relief by visual analog scores at 30 and 60 minutes. Statistical analysis was performed using Mann-Whitney Utest for nonparametric analysis and repeated-measures analysis of variance.

Forty-six received morphine sulfate and 48 received butorphanol. There was no difference in demographics in the two groups.

Conclusion: Females had better pain scores with butorphanol than morphine at 60 minutes. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable.

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Sibille KT, et al. Pain Med. Epub Jun Clinical Trial.

Comparison of epidural butorphanol versus epidural morphine in postoperative pain relief. Parikh GP, et al. Middle East J Anaesthesiol.

A double-blind randomized clinical trial evaluating the analgesic efficacy of ketorolac versus butorphanol for patients with suspected biliary colic in the emergency department. Olsen JC, et al.

Acad Emerg Med. Epub Jul Opioid agonist-antagonist drugs in acute and chronic pain states. Hoskin PJ, et al. PMID: Review. Butorphanol prevents morphine-induced pruritus without increasing pain and other side effects: a systematic review of randomized controlled trials.

Du BX, et al. Can J Anaesth. See all similar articles.

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Mauvais-Jarvis F, et al. Pharmacol Rev. PMID: Stamenkovic DM, et al. Front Pharmacol. Shirai T, et al. Epub Nov Impact of sex on pain San antonio discreet sex opioid analgesia: a review. Fullerton EF, et al.

Curr Opin Behav Sci. Epub Sep 3. Neuronal and glial factors contributing to sex differences in opioid modulation of pain. Averitt DL, et al.

Sex differences in analgesia: a randomized trial of mu versus kappa opioid agonists

See all "Cited by" articles. Publication types Clinical Trial Actions. Randomized Controlled Trial Actions. Research Support, Non-U. Gov't Actions. MeSH terms Adult Actions. Analysis of Variance Actions. Double-Blind Method Actions. Emergency Service, Hospital Actions.

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Humans Actions. Male Actions. Pain Measurement Actions.

Time Factors Actions. Treatment Outcome Actions. Substances Analgesics, Opioid Actions. Narcotic Antagonists Actions. Morphine Actions. Butorphanol Actions. Full text links [x] Southern Medical Association. Copy Download.

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